![]() The cDC1 subset constitutes a homogeneous cell population identified by surface expression of the chemokine receptor XCR1 and the C-type lectin DNGR-1 (also known as CLEC9A) in both mice and humans ( Crozat et al., 2010, Poulin et al., 2012) and is defined by its developmental dependence on the transcription factors BATF3 and IRF8 ( Aliberti et al., 2003, Hildner et al., 2008, Murphy et al., 2016) and the growth factors fms-like tyrosine kinase 3 ligand (FLT3L) and granulocyte-macrophage colony-stimulating factor (GM-CSF) ( Ginhoux et al., 2009, Greter et al., 2012, McKenna et al., 2000, Merad et al., 2013). They are classically divided into plasmacytoid DCs (pDCs) and two distinct subsets of conventional DCs (cDCs), termed cDC1 and cDC2 ( Guilliams et al., 2014). ![]() Dendritic cells (DCs) are mononuclear phagocytes crucial for the initiation and regulation of immune responses ( Steinman et al., 2003).
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